SGK1 inhibition shortens action potential duration and exerts anti-arrhythmic effects in LQT3 mice and LQT2 rabbits by reducing enhanced late sodium current

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SGK1 inhibition shortens action potential duration and exerts anti-arrhythmic effects in LQT3 mice and LQT2 rabbits by reducing enhanced late sodium current

Session: Molecular and cellular drivers of arrhythmia

Topic: Ion Channels, Electrophysiology

Speaker: Doctor S. Casini (Amsterdam, NL)

Event: ESC Congress 2025

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Doctor Simona Casini

Amsterdam University Medical Centre (AUMC), Amsterdam (Netherlands (The))

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4 more presentations in this session

Investigation of a novel SLC4A3 variant causing short QT Syndrome: functional and pharmacological evaluation in a knock-in zebrafish model

Speaker: Ms M. Zhu (Suita, JP)

DECA11 selectively increases human INa and IK1 and is antiarrhythmic in a mouse model of heart failure

Speaker: Professor R. Caballero (Madrid, ES)

Atrial electrophysiological disturbances caused by disruption of the RBM20 splicing factor

Speaker: Mr L. Weirauch (Heidelberg, DE)

Engineered pluripotent stem cell-derived cardiomyocytes prevent serious engraftment-related arrhythmia in nonhuman primates

Speaker: Associate Professor K. Nakamura (Seattle, US)

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Molecular and cellular drivers of arrhythmia

Speakers: Doctor S. Casini, Ms M. Zhu, Professor R. Caballero, Mr L. Weirauch, Associate Professor K. Nakamura

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ESC Congress 2025

29 August - 1 September 2025

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