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Doctor Chantal Jm van Opbergen

Amsterdam University Medical Centre, Amsterdam (Netherlands (The))

Dr. Chantal J.M. van Opbergen is a postdoctoral research fellow whose work centers on uncovering the molecular and cellular mechanisms underlying arrhythmogenic cardiomyopathy (ARVC) and mechanisms of cardiac arrhythmias in other inherited cardiomyopathies. She earned her PhD from Utrecht University (2020) by investigating calcium-sensitive pathways in ARVC, and subsequently continued her research at New York University School of Medicine (2019) and Amsterdam UMC (2023). Here, she focuses on multidisciplinary projects that bridge preclinical discovery with translational applications; including a gene therapy approach for PKP2-ARVC resulting in a Phase 1 FDA-approved clinical trial.

Leaky RyR2 channels as pro-arrhythmic trigger in the PKP2-deficient atrial myocardium

Event: Frontiers in CardioVascular Biomedicine 2024

Topic: Arrhythmias

Session: Pro-arrhythmic mechanisms and anti-arrhythmic strategies

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Blockade of the adenosine 2A receptor mitigates the cardiomyopathy induced by loss of plakophilin-2 expression

Event: EHRA 2019

Topic: Arrhythmias

Session: Poster Session 1 - 43rd EWGCCE Meeting

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Optogenetic sensors in zebrafish hearts as novel in vivo electrophysiological readout tools to study cardiac arrhythmogenesis

Event: Frontiers in CardioVascular Biology 2018

Topic: Arrhythmias

Session: Basic Science - Cardiac Diseases

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