Florian Wenzl, MD FESC trained at the University of Pennsylvania and the German Heart Centre before joining the University of Zurich in 2021. Florian and his team aim at refining personalised treatment approaches using AI and emerging biomarkers. He developed the machine learning-based GRACE 3.0 score for early risk stratification of patients with NSTE-ACS as well as novel cardio-metabolic and cardio-renal risk algorithms for optimised residual risk management. Florian is involved in various ongoing RCTs investigating new translational treatment strategies, funded by the European Union and other bodies. For his efforts in research and education, he received several awards. Florian is part of the UK Disease Registration and Analysis Service and the Karolinska Institutet, and serves on the ESC Committee on Digital Cardiology & AI and the steering committee of the Swiss National Registry of Myocardial Infarction.